PROBIOTICI U LEČENJU ATOPIČKOG DERMATITISA - ISTINA ILI MIT KOJA JE EFIKASNOST PROBIOTIKA U SMANJENJU SIMPTOMA EKCEMA I POBOLJŠANJU KVALITETA ŽIVOTA DECE OBOLELE OD EKCEMA?

Autori

DOI:

https://doi.org/10.46793/PP250228007C

Ključne reči:

atopijski dermatitis, deca, probiotici, prevencija

Apstrakt

Atopijski dermatitis (AD) je najčešći hronični inflamatorni poremećaj kože, pogađa čak 20% dece. AD je obično prvi korak atopijskog marša, sa uzastopnom progresijom ka respiratornim alergijskim bolestima (astma i alergijski rinitis). Cilj ove prospektivne studije  bio je da se prati efikasnost mešavine 3x109 CFU od 3 probiotička soja Lactobacillus Casei BL 2401, Lactobacillus Salivarius BL 2201, Bifidobacterium Breve BL 3406 u kombinaciji sa 7mh cinka u Hipro-ri formi resor za bolju resorpciju i sa 1200 IJ Vitamin D3 (Imunolak Kids D3 Zn),  u grupi dece sa atopijskim dermatitisom. Tretman je trajao 3 meseca. Deca sa blagim do umerenim AD koja su primala Imunolak Kids D3 Zn praćena su narednih 6 meseci nakon prestanka uzimanja probiotika zbog AD i bolesti respiratornog trakta. Naše zapažanje je pokazalo da je 6 meseci nakon prestanka upotrebe probiotika, AD simptomi su bili pod kontrolom, dok su respiratorne tegobe bile ređe tokom 3 meseca upotrebe probiotika, ali ne i nakon završene terapije.

Reference

Weidinger S, Novak N. Atopic dermatitis. Lancet. 2016;387(10023):1109-1122. doi: 10.1016/S0140-6736(15)00149-X. PMID: 26377142.

Bieber T. Disease modification in inflammatory skin disorders: opportunities and challenges. Nat Rev Drug Discov. 2023;22(8):662-680. doi: 10.1038/s41573-023-00735-0. Erratum in: Nat Rev Drug Discov. 2023;22(11):935. doi: 10.1038/s41573-023-00790-7. PMID: 37443275.

Sjögren YM, Jenmalm MC, Böttcher MF, Björkstén B, Sverremark-Ekström E. Altered early infant gut microbiota in children developing allergy up to 5 years of age. Clin Exp Allergy. 2009;39(4):518-26. doi: 10.1111/j.1365-2222.2008.03156.x. PMID: 19220322.

West CE, Jenmalm MC, Prescott SL. The gut microbiota and its role in the development of allergic disease: a wider perspective. Clin Exp Allergy. 2015;45(1):43-53. doi: 10.1111/cea.12332. PMID: 24773202.

Galli E, Cinicola B, Carello R, Caimmi S, Brindisi G, De Castro G, et al. Atopic dermatitis. Acta Biomed. 2020 Sep 15;91(11-S):e2020011. doi: 10.23750/abm.v91i11-S.10313. PMID: 33004781.

Boguniewicz M, Alexis AF, Beck LA, Block J, Eichenfield LF, Fonacier L, et al. Expert Perspectives on Management of Moderate-to-Severe Atopic Dermatitis: A Multidisciplinary Consensus Addressing Current and Emerging Therapies. J Allergy Clin Immunol Pract. 2017;5(6):1519-1531. doi: 10.1016/j.jaip.2017.08.005. PMID: 28970084.

Čelakovská J, Bukač J, Vaňková R, Krejsek J, Andrýs, Andrýs C. The relation between the sensitization to molecular components of inhalant allergens and food reactions in patients suffering from atopic dermatitis. Food Agric Immunol. 2021;32(1):33–53.doi: 10.1080/09540105.2020.1865281

Čelakovská J, Krcmova I, Bukac J, Vaneckova J. Sensitivity and specificity of specific IgE, skin prick test and atopy patch test in examination of food allergy. Food Agric Immunol. 2017;28:238–247. doi: 10.1080/09540105.2016.1258548

Kantor R, Silverberg JI. Environmental risk factors and their role in the management of atopic dermatitis. Expert Rev Clin Immunol 2017;13(1):15–26. doi: 10.1080/1744666X.2016.1212660

Wopereis H, Oozeer R, Knipping K, Belzer C, Knol J. The first thousand days - intestinal microbiology of early life: establishing a symbiosis. Pediatr Allergy Immunol. 2014;25(5):428-438. doi: 10.1111/pai.12232

Fiocchi A, Pawankar R, Cuello-Garcia C, Ahn K, Al-Hammadi S, Agarwal A, et al. World Allergy Organization-McMaster University Guidelines for Allergic Disease Prevention (GLAD-P): Probiotics. World Allergy Organ J. 2015;8(1):4. doi: 10.1186/s40413-015-0055-2. PMID: 25628773.

Kalliomäki M, Salminen S, Arvilommi H, Kero P, Koskinen P, Isolauri E. Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial. Lancet. 2001;357(9262):1076-9. doi: 10.1016/S0140-6736(00)04259-8. PMID: 11297958.

Husein-ElAhmed H, Steinhoff M. Effects of probiotic supplementation in adult with atopic dermatitis: a systematic review with meta-analysis. Clin Exp Dermatol. 2023;49(1):46-52. doi: 10.1093/ced/llad318. PMID: 37706436.

Filipovic I, Ostojic O, Vekovic V, Mihajlovic S, Caminati M, Zivkovic Z. Efficacy of Specially Formulated Combination Three Probiotic Strains with Vitamin D3 and Zn in Children with Atopic Dermatitis. Am J Pediatr. 2023;9(4):186-192. doi: 10.11648/j.ajp.20230904.11

Chkhaidze N, Kherkheulidze M, Chkhaidze I. Probiotics for the prevention of ventilator-associated pneumonia. Prev Ped 2024;10(1-2):33-38. https://doi.org/10.46793/PP231110006C

##submission.downloads##

Objavljeno

03/20/2025

Broj časopisa

Sekcija

Review Articles