THE IMPORTANCE OF PRECISION MEDICINE AND PHARMACOGENOMICS IN PREVENTIVE PEDIATRICS
DOI:
https://doi.org/10.46793/PP240127011KKeywords:
Precision medicine, multiomics, prevention, pediatricsAbstract
Disease prevention includes all activities that could be used to prevent the occurrence and manifestation of disease manifestations, to detect the disease early and to apply appropriate therapy in a timely manner.
Implementation of precision medicine strategies include genetic analyses, factors of the external environment as well as the way a person lives, to precisely select the treatment that is most appropriate and effective for that person.
Precision medicine also includes information obtained from genetic tests - the so-called. "OMICS" (GEN-omics, TRANSCRIPT-omics, EPIGEN-omics, METABOL-omics, PROTE-omics, MICRO-omics), i.e. technologies and data analyzes that provide accurate clinical, biological and molecular phenotype.
Precision medicine opens the chapter of health care, preventive medicine and preventive pediatrics.
Improving lifestyle and avoiding harmful environmental factors could affect gene function, and could be use in prevention and development of precise preventive health strategies.
References
Stenzinger A, Moltzen EK, Winkler E, et al. Implementation of precision medicine in healthcare-A European perspective. J Intern Med. 2023;294(4):437-454. doi:10.1111/joim.13698; PMID: 37455247
Goetz LH, Schork NJ. Personalized medicine: motivation, challenges, and progress. Fertil Steril. 2018;109(6):952-963. doi:10.1016/j.fertnstert.2018.05.006; PMID: 29935653
Petzschner FH. Practical challenges for precision medicine. Science. 2024;383(6679):149-150. doi:10.1126/science.adm9218; PMID: 38207033
Tufail M, Hu JJ, Liang J, et al. Predictive, preventive, and personalized medicine in breast cancer: targeting the PI3K pathway. J Transl Med. 2024;22(1):15. Published 2024 Jan 3. doi:10.1186/s12967-023-04841-w; PMID: 38172946
Ramaswami R, Bayer R, Galea S. Precision Medicine from a Public Health Perspective. Annu Rev Public Health. 2018;39:153-168. doi:10.1146/annurev-publhealth-040617-014158; PMID: 29166244
Di Sanzo M, Cipolloni L, Borro M, et al. Clinical Applications of Personalized Medicine: A New Paradigm and Challenge. Curr Pharm Biotechnol. 2017;18(3):194-203. doi:10.2174/1389201018666170224105600; PMID: 28240172
Cirillo D, Valencia A. Big data analytics for personalized medicine. Curr Opin Biotechnol. 2019;58:161-167. doi:10.1016/j.copbio.2019.03.004; PMID: 30965188
Maier M. Personalized medicine-a tradition in general practice!. Eur J Gen Pract. 2019;25(2):63-64. doi:10.1080/13814788.2019.1589806; PMID: 31032696
Cacabelos R. Pharmacogenomics: A gateway to personalized medicine. Farmacogenómica: Una puerta de acceso a la medicina personalizada. Med Clin (Barc). Published online December 22, 2023. doi:10.1016/j.medcli.2023.11.008; PMID: 38142210
Vnencak-Jones CL, Saucier LAG, Liu M, Gatto CL, Peterson JF. Pharmacogenomics: Genotype-Driven Medicine. J Appl Lab Med. 2024;9(1):183-186. doi:10.1093/jalm/jfad064; PMID: 38167767
Kolodziejczyk AA, Zheng D, Elinav E. Diet-microbiota interactions and personalized nutrition. Nat Rev Microbiol. 2019;17(12):742-753. doi:10.1038/s41579-019-0256-8; PMID: 31541197
Chan IS, Ginsburg GS. Personalized medicine: progress and promise. Annu Rev Genomics Hum Genet. 2011;12:217-244. doi:10.1146/annurev-genom-082410-101446; PMID: 21721939
Franks PW, Cefalu WT, Dennis J, et al. Precision medicine for cardiometabolic disease: a framework for clinical translation. Lancet Diabetes Endocrinol. 2023;11(11):822-835. doi:10.1016/S2213-8587(23)00165-1; PMID: 37804856
Antman EM, Loscalzo J. Precision medicine in cardiology. Nat Rev Cardiol. 2016;13(10):591-602. doi:10.1038/nrcardio.2016.101; PMID: 27356875
Tesi B, Boileau C, Boycott KM, et al. Precision medicine in rare diseases: What is next?. J Intern Med. 2023;294(4):397-412. doi:10.1111/joim.13655; PMID: 37211972
Schiavone S, Neri M, Pomara C, Riezzo I, Trabace L, Turillazzi E. Personalized Medicine in the Paediatric Population: The Balance Between Pharmacogenetic Progress and Bioethics. Curr Pharm Biotechnol. 2017;18(3):253-262. doi:10.2174/1389201018666170207130236; PMID: 28176639
Babu M, Snyder M. Multi-Omics Profiling for Health. Mol Cell Proteomics. 2023;22(6):100561. doi:10.1016/j.mcpro.2023.100561; PMID: 37119971
Attwaters M. Bridging the multi-omics gap. Nat Rev Genet. 2023;24(8):488. doi:10.1038/s41576-023-00632-7; PMID: 37340169
Tompkins JD. Transgenerational Epigenetic DNA Methylation Editing and Human Disease. Biomolecules. 2023;13(12):1684. Published 2023 Nov 22. doi:10.3390/biom13121684; PMID: 38136557
Anaya JM, Duarte-Rey C, Sarmiento-Monroy JC, Bardey D, Castiblanco J, Rojas-Villarraga A. Personalized medicine. Closing the gap between knowledge and clinical practice. Autoimmun Rev. 2016;15(8):833-842. doi:10.1016/j.autrev.2016.06.005; PMID: 27302209