IMMUNE SYSTEM IN PREGNANCY
Keywords:
immune system, pregnancy, pro-inflammatory and anti-inflammatory condition, immune clockAbstract
Introduction: Pregnant women are considered as special population group due to a change in status of the immune system caused by pregnancy. The mother's immune system plays a key role in the development of the child during pregnancy, but changes in circulating immune mediators of mother and newborn are associated with complications of pregnancy as well as susceptibility to autoimmune and neurodevelopment conditions in the child. Therefore, it is important to explore this area that presents a challenge for decision making on how to access, prevent, and treat inflammatory and infectious diseases in pregnant women, to avoid adverse outcomes for both mother and child.
Summary: There is no consensus in the literature on the understanding of the pregnant woman's immune system as a pro-inflammatory or anti-inflammatory condition. However, there is agreement in all research articles that pregnancy cannot be viewed as a single event and that in reality there are three different stages that characterize different biological and immune processes that actually symbolize how a pregnant woman feels.
The purpose of this study is to present a systematic review of available evidence-based literature, concerning the changes in adaptive and acquired immunity in pregnancy, as well as the existence of an “immune clock” that is considered crucial for seeking chronological abnormalities associated with pregnancy pathologies.
Conclusion: This study informs us about neurological changes and dysregulation during pregnancy, which can potentially lead to outcomes such as preeclampsia, intrauterine growth restriction and miscarriage.
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