NEW INSIGHTS IN NON-INVASIVE DIAGNOSIS OF PEDIATRIC ASTHMA - KEY ROLE FOR EARLY PREVENTION
Keywords:pediatric asthma, diagnosis, monitoring
In routine clinical practice, the diagnosis of asthma in children is mainly based on clinical criteria. Recently the assessment of physiological and pathological processes through biomarkers can support the diagnosis of asthma, help in monitoring and improving the treatment outcomes and prevention of the morbidity rate. The identification and validation of biomarkers in pediatric asthma has emerged as a top priority among leading experts, researchers, and clinicians. The use of non-invasive biomarkers is highly supported in recent guidelines for the diagnosis of asthma in adult patients, on the other hand, when it comes to the pediatric population, data are still quite limited. The most studied biomarkers include spirometry, markers of allergic sensitization and fractional exhaled nitric oxide (FeNO). Newer markers measured in exhaled air and "omics" approaches provide information on specific asthma phenotypes, however, their clinical applicability is still insufficiently elucidated. This review aims to summarize and discuss the available data on the use of non-invasive biomarkers in the diagnosis and monitoring of children with asthma.
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